About BioStats

BioStats, founded in 2017 by Dr. Alexander Krannich, is headquartered near Berlin, Germany. As a leading provider of statistical analysis and data science services, we specialize in assisting medical technology companies, biotechnology firms, and pharmaceutical companies in achieving product success. With our expertise and dedication to excellence, we have established ourselves as a trusted partner in the industry.

Our team of experienced statisticians and data scientists brings together a wealth of knowledge and skills in statistics, data science, and data management. We are passionate about helping our clients unlock the full potential of their products through the power of data-driven insights.

At BioStats, we believe in the importance of academic collaborations and staying closely connected to the needs of patients. We actively engage in partnerships with academic institutions and research organizations to stay at the forefront of scientific advancements and contribute to the development of innovative solutions.

We understand that the ultimate measure of success lies in the impact our work has on patients‘ lives. That’s why we are committed to applying our expertise to support the development of products that directly benefit patients, ensuring their health, safety, and improved quality of life.

A selection of our partners

Topic-specific publications

Last top publication

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

PMID: 32591762 DOI: 10.1038/s41587-020-0602-4


Last medical publication

The role of cell-free hemoglobin and haptoglobin in acute kidney injury in critically ill adults with ARDS and therapy with VV ECMO

PMID: 35193645 PMCID: PMC8864920 DOI: 10.1186/s13054-022-03894-5


Last medical publication

Discriminant Analysis with Biomedical Examples



Complete publication list

Publications 2023


  1. Leonhardt S, Jürgensen C, Frohme J, Grajecki D, Adler A, Sigal M, Leonhardt J, Voll JM, Kruse JM, Körner R, Eckardt KU, Janssen HJ, Gebhardt V, Schmittner MD; Pa-COVID-19 collaborative study group [Krannich A]; Frey C, Müller-Ide H, Bauer M, Thibeault C, Kurth F, Sander LE, Müller T, Tacke F. Hepatobiliary long-term consequences of COVID-19: dramatically increased rate of secondary sclerosing cholangitis in critically ill COVID-19 patients. Hepatol Int. 2023 Apr 29:1-16. doi: 10.1007/s12072-023-10521-0. PMID: 37119516


  1. Bünger V, Hunsicker O, Krannich A, Balzer F, Spies CD, Kuebler WM, Weber-Carstens S, Menk M, Graw JA. Potential of cell-free hemoglobin and haptoglobin as prognostic markers in patients with ARDS and treatment with veno-venous ECMO. J Intensive Care. 2023 Apr 20;11(1):15. doi: 10.1186/s40560-023-00664-5. PMID: 37081577


  1. Lechner K, Bock M, von Schacky C, Scherr J, Lorenz E, Lechner B, Haller B, Krannich A, Halle M, Wachter R, Duvinage A, Edelmann F. Trans-fatty acid blood levels of industrial but not natural origin are associated with cardiovascular risk factors in patients with HFpEF: a secondary analysis of the Aldo-DHF trial. Clin Res Cardiol. 2023 Jan 14. doi: 10.1007/s00392-022-02143-7. Epub ahead of print. PMID: 36640187.


Publications 2022


  1. Koll CEM, Hopff SM, Meurers T, Lee CH, Kohls M, Stellbrink C, Thibeault C, Reinke L, Steinbrecher S, Schreiber S, Mitrov L, Frank S, Miljukov O, Erber J, Hellmuth JC, Reese JP, Steinbeis F, Bahmer T, Hagen M, Meybohm P, Hansch S, Vadász I, Krist L, Jiru-Hillmann S, Prasser F, Vehreschild JJ; NAPKON Study Group (Krannich A). Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients. Sci Data. 2022 Dec 21;9(1):776. doi: 10.1038/s41597-022-01669-9. PMID: 36543828; PMCID: PMC9769467.


  1. Lechner K, von Schacky C, Scherr J, Lorenz E, Bock M, Lechner B, Haller B, Krannich A, Halle M, Wachter R, Duvinage A, Edelmann F. Saturated Fatty Acid Blood Levels and Cardiometabolic Phenotype in Patients with HFpEF: A Secondary Analysis of the Aldo-DHF Trial. Biomedicines. 2022 Sep 15;10(9):2296. doi: 10.3390/biomedicines10092296. PMID: 36140396; PMCID: PMC9496272.


  1. Piatek K, Feuerstein A, Zach V, Rozados da Conceicao C, Beblo A, Belyavskiy E, Pieske-Kraigher E, Krannich A, Schwedhelm E, Hinz S, Pieske B, Edelmann F. Nitric oxide metabolites: associations with cardiovascular biomarkers and clinical parameters in patients with HFpEF. ESC Heart Fail. 2022 Aug 18. doi: 10.1002/ehf2.14116. Epub ahead of print. PMID: 35979962.


  1. Elsanhoury A, Kühl U, Stautner B, Klein O, Krannich A, Morris D, Willner M, Jankowska E, Klingel K, Van Linthout S, Tschöpe C. The Spontaneous Course of Human Herpesvirus 6 DNA-Associated Myocarditis and the Effect of Immunosuppressive Intervention. 2022 Jan 31;14(2):299. doi: 10.3390/v14020299. PMID: 35215893; PMCID: PMC8879301.


  1. Graw JA, Hildebrandt P, Krannich A, Balzer F, Spies C, Francis RC, Kuebler WM, Weber-Carstens S, Menk M, Hunsicker O. The role of cell-free hemoglobin and haptoglobin in acute kidney injury in critically ill adults with ARDS and therapy with VV ECMO. Crit Care. 2022 Feb 22;26(1):50. doi: 10.1186/s13054-022-03894-5. PMID: 35193645; PMCID: PMC8864920.


  1. Stockmann H, Thelen P, Stroben F, Pigorsch M, Keller T, Krannich A, Spies C, Treskatsch S, Ocken M, Kunz JV, Krüger A, Khadzhynov D, Kron S, Budde K, Eckardt KU, Enghard P, Lehner LJ. CytoSorb Rescue for COVID-19 Patients With Vasoplegic Shock and Multiple Organ Failure: A Prospective, Open-Label, Randomized Controlled Pilot Study. Crit Care Med. 2022 Jun 1;50(6):964-976. doi: 10.1097/CCM.0000000000005493. Epub 2022 Feb 9. PMID: 35135967; PMCID: PMC9112514.


  1. Graw JA, Bünger V, Materne LA, Krannich A, Balzer F, Francis RCE, Pruß A, Spies CD, Kuebler WM, Weber-Carstens S, Menk M, Hunsicker O. Age of Red Cells for Transfusion and Outcomes in Patients with ARDS. J Clin Med. 2022 Jan 4;11(1):245. doi: 10.3390/jcm11010245. PMID: 35011986; PMCID: PMC8745782.



Publications 2021

(Book Chapter)


  1. Klaus-D. Wernecke, Constanze D. Luettke, Jan Multmeier, Marie Schild, Alexander Krannich, Discriminant Analysis with Biomedical Examples, Wiley StatsRef 2021 Aug 18, https://doi.org/10.1002/9781118445112.stat06940.pub2



Publications 2021


  1. Hadzibegovic S, Lena A, Churchill TW, Ho JE, Potthoff S, Denecke C, Rösnick L, Heim KM, Kleinschmidt M, Sander LE, Witzenrath M, Suttorp N, Krannich A, Porthun J, Friede T, Butler J, Wilkenshoff U, Pieske B, Landmesser U, Anker SD, Lewis GD, Tschöpe C, Anker MS. Heart Failure with preserved ejection fraction according to the HFA-PEFF score in COVID-19 patients: clinical correlates and echocardiographic findings. Eur J Heart Fail. 2021 May 1. doi: 10.1002/ejhf.2210. Epub ahead of print. PMID: 33932255.


  1. Lechner K, Scherr J, Lorenz E, Lechner B, Haller B, Krannich A, Halle M, Wachter R, Duvinage A, Edelmann F. Omega-3 fatty acid blood levels are inversely associated with cardiometabolic risk factors in HFpEF patients: the Aldo-DHF randomized controlled trial. Clin Res Cardiol. 2022 Mar;111(3):308-321. doi: 10.1007/s00392-021-01925-9. Epub 2021 Aug 28. PMID: 34453204; PMCID: PMC8873063.


  1. Hillus D, Schwarz T, Tober-Lau P, Vanshylla K, Hastor H, Thibeault C, Jentzsch S, Helbig ET, Lippert LJ, Tscheak P, Schmidt ML, Riege J, Solarek A, von Kalle C, Dang-Heine C, Gruell H, Kopankiewicz P, Suttorp N, Drosten C, Bias H, Seybold J; EICOV/COVIM Study Group (Krannich A), Klein F, Kurth F, Corman VM, Sander LE. Safety, reactogenicity, and immunogenicity of homologous and heterologous prime- boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study. Lancet Respir Med. 2021 Nov;9(11):1255-1265. doi: 10.1016/S2213-2600(21)00357-X. Epub 2021 Aug 13. PMID: 34391547; PMCID: PMC8360702.


  1. Mühlemann B, Thibeault C, Hillus D, Helbig ET, Lippert LJ, Tober-Lau P, Schwarz T, Müller MA; Pa-COVID-19 collaborative study group (Krannich A), Witzenrath M, Suttorp N, Sander LE, Drosten C, Jones TC, Corman VM, Kurth F. Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study. Clin Microbiol Infect. 2021 Oct;27(10):1520.e7-1520.e10. doi: 10.1016/j.cmi.2021.06.008. Epub 2021 Jun 15. PMID: 34139335; PMCID: PMC8205283.


  1. Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe- Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group (Krannich A), Ralser M, Kurth F. A time-resolved proteomic and prognostic map of COVID-19. Cell Syst. 2021 Aug 18;12(8):780-794.e7. doi: 10.1016/j.cels.2021.05.005. Epub 2021 Jun 14. PMID: 34139154; PMCID: PMC8201874.


  1. Thibeault C, Mühlemann B, Helbig ET, Mittermaier M, Lingscheid T, Tober-Lau P, Meyer-Arndt LA, Meiners L, Stubbemann P, Haenel SS, Bosquillon de Jarcy L, Lippert L, Pfeiffer M, Stegemann MS, Roehle R, Wiebach J, Hippenstiel S, Zoller T, Müller-Redetzky H, Uhrig A, Balzer F, von Kalle C, Suttorp N, Jones TC, Drosten C, Witzenrath M, Sander LE; Pa-COVID Study Group (Krannich A), Corman VM, Kurth F. Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study. 2021 Aug;49(4):703-714. doi: 10.1007/s15010-021-01594-w. Epub 2021 Apr 22. PMID: 33890243; PMCID: PMC8061715.


  1. Gül-Klein S, Kästner A, Haber PK, Krenzien F, Wabitsch S, Krannich A, Andreou A, Eurich D, Tacke F, Horst D, Pratschke J, Schmelzle M. Recurrence of Hepatocellular Carcinoma After Liver Transplantation is Associated with Episodes of Acute Rejections. J Hepatocell Carcinoma. 2021 Mar 18;8:133-143. doi: 10.2147/JHC.S292010. PMID: 33777855; PMCID: PMC7987264.


  1. Hommes F, van Loon W, Thielecke M, Abramovich I, Lieber S, Hammerich R, Gehrke-Beck S, Linzbach E, Schuster A, von dem Busche K, Theuring S, Gertler M, Martinez GE, Richter J, Bergmann C, Bölke A, Böhringer F, Mall MA, Rosen A, Krannich A, Keller J, Bethke N, Kurzmann M, Kurth T, Kirchberger V, Seybold J, Mockenhaupt FP, Study Group B. SARS-CoV-2 Infection, Risk Perception, Behaviour and Preventive Measures at Schools in Berlin, Germany, during the Early Post-Lockdown Phase: A Cross-Sectional Study. Int J Environ Res Public Health. 2021 Mar 8;18(5):2739. doi: 10.3390/ijerph18052739. PMID: 33800392; PMCID:



  1. Hunsicker O, Beck L, Krannich A, Finger T, Prinz V, Spies C, Weber-Carstens S, Wolf S, Graw JA, Menk M. Timing, Outcome, and Risk Factors of Intracranial Hemorrhage in Acute Respiratory Distress Syndrome Patients During Venovenous Extracorporeal Membrane Oxygenation. Crit Care Med. 2021 Feb 1;49(2):e120-e129. doi: 10.1097/CCM.0000000000004762. PMID: 33323749.



Publications 2020


  1. Hunsicker O, Materne L, Bünger V, Krannich A, Balzer F, Spies C, Francis RC, Weber-Carstens S, Menk M, Graw JA. Lower versus higher hemoglobin threshold for transfusion in ARDS patients with and without ECMO. Crit Care. 2020 Dec 16;24(1):697. doi: 10.1186/s13054-020-03405-4. PMID: 33327953; PMCID: PMC7740070.


  1. Chua RL, Lukassen S, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski J, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H, Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R. COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis. Nat Biotechnol. 2020 Aug;38(8):970-979. doi: 10.1038/s41587-020-0602-4. Epub 2020 Jun 26. PMID: 32591762.


  1. Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE. Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19). 2020 Aug;48(4):619-626. doi: 10.1007/s15010-020-01464-x. Epub 2020 Jun 13. PMID: 32535877; PMCID: PMC7293426.


  1. Müller I, Vogl T, Kühl U, Krannich A, Banks A, Trippel T, Noutsias M, Maisel AS, van Linthout S, Tschöpe C. Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis. ESC Heart Fail. 2020 Aug;7(4):1442-1451. doi: 10.1002/ehf2.12760. Epub 2020 May 28. PMID: 32462801; PMCID: PMC7373886.



Publications 2019


  1. Hunsicker O, Gericke S, Graw JA, Krannich A, Boemke W, Meyer O, Braicu I, Spies C, Sehouli J, Pruß A, Feldheiser A. Transfusion of red blood cells does not impact progression-free and overall survival after surgery for ovarian cancer. 2019 Dec;59(12):3589-3600. doi: 10.1111/trf.15552. Epub 2019 Oct 21. PMID: 31633819.


  1. Nee J, Jörres A, Krannich A, Leithner C, Schroeder T, Munk AL, Enghard P, Moore C, Steppan S, Storm C. Elimination of glutamate using CRRT for 72 h in patients with post-cardiac arrest syndrome: A randomized clinical pilot trial. 2019 Nov;144:54-59. doi: 10.1016/j.resuscitation.2019.09.020. Epub 2019 Sep 23. PMID: 31557520.


  1. Storm C, Leithner C, Krannich A, Suarez JI, Stevens RD. Impact of Structured Pathways for Postcardiac Arrest Care: A Systematic Review and Meta-Analysis. Crit Care Med. 2019 Aug;47(8):e710-e716. doi: 10.1097/CCM.0000000000003827. PMID: 31306259.


  1. Bartolomaeus H, Balogh A, Yakoub M, Homann S, Markó L, Höges S, Tsvetkov D, Krannich A, Wundersitz S, Avery EG, Haase N, Kräker K, Hering L, Maase M, Kusche-Vihrog K, Grandoch M, Fielitz J, Kempa S, Gollasch M, Zhumadilov Z, Kozhakhmetov S, Kushugulova A, Eckardt KU, Dechend R, Rump LC, Forslund SK, Müller DN, Stegbauer J, Wilck N. Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage. 2019 Mar 12;139(11):1407-1421. doi: 10.1161/CIRCULATIONAHA.118.036652. PMID: 30586752; PMCID: PMC6416008.



Publications 2018


  1. Storm C, Krannich A, Schachtner T, Engels M, Schindler R, Kahl A, Otto NM. Impact of acute kidney injury on neurological outcome and long-term survival after cardiac arrest – A 10 year observational follow up. J Crit Care. 2018 Oct;47:254-259. doi: 10.1016/j.jcrc.2018.07.023. Epub 2018 Jul 23. PubMed PMID: 30071447.


  1. Hunsicker O, Hessler K, Krannich A, Boemke W, Braicu I, Sehouli J, Meyer O, Pruß A, Spies C, Feldheiser A. Duration of storage influences the hemoglobin rising effect of red blood cells in patients undergoing major abdominal surgery. 2018 Aug;58(8):1870-1880. doi: 10.1111/trf.14627. Epub 2018 Apr 17.  PubMed PMID: 29665067.


  1. Winterer G, Androsova G, Bender O, Boraschi D, Borchers F, Dschietzig TB, Feinkohl I, Fletcher P, Gallinat J, Hadzidiakos D, Haynes JD, Heppner F, Hetzer S, Hendrikse J, Ittermann B, Kant IMJ, Kraft A, Krannich A, Krause R, Kühn S, Lachmann G, van Montfort SJT, Müller A, Nürnberg P, Ofosu K, Pietsch M, Pischon T, Preller J, Renzulli E, Scheurer K, Schneider R, Slooter AJC, Spies C, Stamatakis E, Volk HD, Weber S, Wolf A, Yürek F, Zacharias N; BioCog consortium. Personalized risk prediction of postoperative cognitive impairment – rationale for the EU-funded BioCog project. Eur Psychiatry. 2018 Apr;50:34-39. doi: 10.1016/j.eurpsy.2017.10.004. Epub 2018 Feb 3. PubMed PMID: 29398565.


  1. Salatzki J, Foryst-Ludwig A, Bentele K, Blumrich A, Smeir E, Ban Z, Brix S, Grune J, Beyhoff N, Klopfleisch R, Dunst S, Surma MA, Klose C, Rothe M, Heinzel FR, Krannich A, Kershaw EE, Beule D, Schulze PC, Marx N, Kintscher U. Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure. PLoS Genet. 2018 Jan 10;14(1):e1007171. doi: 10.1371/journal.pgen.1007171. eCollection 2018 Jan. PubMed PMID: 29320510; PubMed Central PMCID: PMC5779697.


  1. Behrens A, Kreuzmayr A, Manner H, Koop H, Lorenz A, Schaefer C, Plauth M, Jetschmann JU, von Tirpitz C, Ewald M, Sackmann M, Renner W, Krüger M, Schwab D, Hoffmann W, Engelke O, Pech O, Kullmann F, Pampuch S, Lenfers B, Weickert U, Schilling D, Boehm S, Beckebaum S, Cicinnati V, Erckenbrecht JF, Dumoulin FL, Benz C, Rabenstein T, Haltern G, Balsliemke M, de Mas C, Kleber G, Pehl C, Vogt C, Kiesslich R, Fischbach W, Koop I, Kuehne J, Breidert M, Sass NL, May A, Friedrich C, Veitt R, Porschen R, Ellrichmann M, Arlt A, Schmitt W, Dollhopf M, Schmidbaur W, Dignass A, Schmitz V, Labenz J, Kaiser G, Krannich A, Barteska N, Ell C. Acute sedation-associated complications in GI endoscopy (ProSed 2 Study):  results from the prospective multicentre electronic registry of sedation-associated complications. 2018 Jan 3. pii: gutjnl-2015-311037. doi: 10.1136/gutjnl-2015-311037. [Epub ahead of print] PubMed PMID: 29298872.


  1. Friedrich CC, Lin Y, Krannich A, Wu Y, Vacanti JP, Neville CM. Enhancing engineered vascular networks in vitro and in vivo: The effects of IGF1 on vascular development and durability. Cell Prolif. 2018 Feb;51(1). doi: 10.1111/cpr.12387. Epub 2017 Nov 7. PubMed PMID: 29110360.


  1. Brandl A, Weiss S, von Winterfeld M, Krannich A, Feist M, Pratschke J, Raue W, Rau B. Predictive value of peritoneal cancer index for survival in patients with mucinous peritoneal malignancies treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a single centre experience. Int J Hyperthermia. 2018 Aug;34(5):512-517. doi: 10.1080/02656736.2017.1351627. Epub 2017 Jul 26. PubMed PMID: 28679331.



Publications 2017


  1. Krampe H, Salz AL, Kerper LF, Krannich A, Schnell T, Wernecke KD, Spies CD. Readiness to change and therapy outcomes of an innovative psychotherapy program for surgical patients: results from a randomized controlled trial. BMC Psychiatry. 2017 Dec 29;17(1):417. doi: 10.1186/s12888-017-1579-5. PubMed PMID: 29284443; PubMed Central PMCID: PMC5747166.


  1. Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, Haase S, Mähler A, Balogh A, Markó L, Vvedenskaya O, Kleiner FH, Tsvetkov D, Klug L, Costea PI, Sunagawa S, Maier L, Rakova N, Schatz V, Neubert P, Frätzer C, Krannich A, Gollasch M, Grohme DA, Côrte-Real BF, Gerlach RG, Basic M, Typas A, Wu C, Titze JM, Jantsch J, Boschmann M, Dechend R, Kleinewietfeld M, Kempa S, Bork P, Linker RA, Alm EJ, Müller DN. Salt-responsive gut commensal modulates T(H)17 axis and disease. 2017 Nov 30;551(7682):585-589. doi: 10.1038/nature24628. Epub 2017 Nov 15. PubMed PMID: 29143823; PubMed Central PMCID: PMC6070150.


  1. Beyhoff N, Brix S, Betz IR, Klopfleisch R, Foryst-Ludwig A, Krannich A, Stawowy P, Knebel F, Grune J, Kintscher U. Application of Speckle-Tracking Echocardiography in an Experimental Model of Isolated Subendocardial Damage. J Am Soc Echocardiogr. 2017 Dec;30(12):1239-1250.e2. doi: 10.1016/j.echo.2017.08.006. Epub 2017 Oct 21. PubMed PMID: 29066223.


  1. Albers AE, Grabow R, Qian X, Jumah MD, Hofmann VM, Krannich A, Pecher G. Efficacy and toxicity of docetaxel combination chemotherapy for advanced squamous cell cancer of the head and neck. Mol Clin Oncol. 2017 Jul;7(1):151-157. doi: 10.3892/mco.2017.1281. Epub 2017 Jun 1. PubMed PMID: 28685095; PubMed Central PMCID: PMC5492725.


  1. Streitberger KJ, Leithner C, Wattenberg M, Tonner PH, Hasslacher J, Joannidis M, Pellis T, Di Luca E, Födisch M, Krannich A, Ploner CJ, Storm C. Neuron-Specific Enolase Predicts Poor Outcome After Cardiac Arrest and Targeted Temperature Management: A Multicenter Study on 1,053 Patients. Crit Care Med. 2017 Jul;45(7):1145-1151. doi: 10.1097/CCM.0000000000002335. PubMed PMID: 28426467.


  1. Storm C, Nee J, Sunde K, Holzer M, Hubner P, Taccone FS, Friberg H, Lopez-de-Sa E, Cariou A, Schefold JC, Ristagno G, Noc M, Donker DW, Andres J, Krawczyk P, Skrifvars MB, Penketh J, Krannich A, Fries M. A survey on general and temperature management of post cardiac arrest patients in large teaching and university hospitals in 14 European countries-The SPAME trial results. 2017 Jul;116:84-90. doi: 10.1016/j.resuscitation.2017.03.038. Epub 2017 Apr 2. PubMed PMID: 28377294.


  1. Hunsicker O, Heinig S, Dathe JJ, Krannich A, Spies C, Feldheiser A. Comparison of bedside assessed arm and leg fluid filtration determined by venous congestion plethysmography in perioperative cancer patients: An observational study investigating agreement. Medicine (Baltimore). 2017 Mar;96(9):e6066. doi: 10.1097/MD.0000000000006066. PubMed PMID: 28248863; PubMed Central PMCID: PMC5340436.


  1. Schwarz C, Brandt C, Antweiler E, Krannich A, Staab D, Schmitt-Grohé S, Fischer R, Hartl D, Thronicke A, Tintelnot K. Prospective multicenter German study on pulmonary colonization with Scedosporium /Lomentospora species in cystic fibrosis: Epidemiology and new association factors. PLoS One. 2017 Feb 8;12(2):e0171485. doi: 10.1371/journal.pone.0171485. eCollection 2017. PubMed PMID: 28178337; PubMed Central PMCID: PMC5298894.


  1. Wylon K, Drozdenko G, Krannich A, Heine G, Dölle S, Worm M. Pharmacokinetic Evaluation of a Single Intramuscular High Dose versus an Oral Long-Term Supplementation of Cholecalciferol. PLoS One. 2017 Jan 23;12(1):e0169620. doi: 10.1371/journal.pone.0169620. eCollection 2017. PubMed PMID: 28114352; PubMed Central PMCID: PMC5256876.


  1. Krannich A, Leithner C, Engels M, Nee J, Petzinka V, Schröder T, Jörres A, Kruse J, Storm C. Isoflurane Sedation on the ICU in Cardiac Arrest Patients Treated With Targeted Temperature Management: An Observational Propensity-Matched Study. Crit Care Med. 2017 Apr;45(4):e384-e390. doi: 10.1097/CCM.0000000000002185. PubMed PMID: 27941501.


  1. Kork F, Balzer F, Krannich A, Bernardi MH, Eltzschig HK, Jankowski J, Spies C. Back-calculating baseline creatinine overestimates prevalence of acute kidney injury with poor sensitivity. Acta Physiol (Oxf). 2017 Mar;219(3):613-624. doi: 10.1111/apha.12763. Epub 2016 Aug 25. PubMed PMID: 27461744.



Publications 2016


  1. Singer E, Schrezenmeier EV, Elger A, Seelow ER, Krannich A, Luft FC, Schmidt-Ott KM. Urinary NGAL-Positive Acute Kidney Injury and Poor Long-term Outcomes in Hospitalized Patients. Kidney Int Rep. 2016 Jul 25;1(3):114-124. doi: 10.1016/j.ekir.2016.07.003. eCollection 2016 Sep. PubMed PMID: 29142920; PubMed Central PMCID: PMC5678650.



  1. Tafelski S, Kerper LF, Salz AL, Spies C, Reuter E, Nachtigall I, Schäfer M, Krannich A, Krampe H. Prospective clinical observational study evaluating gender-associated differences of preoperative pain intensity. Medicine (Baltimore). 2016 Jul;95(27):e4077. doi: 10.1097/MD.0000000000004077. PubMed PMID: 27399095; PubMed Central PMCID: PMC5058824.


  1. Brandt C, Thronicke A, Roehmel JF, Krannich A, Staab D, Schwarz C. Impact of Long-Term Tiotropium Bromide Therapy on Annual Lung Function Decline in Adult Patients with Cystic Fibrosis. PLoS One. 2016 Jun 28;11(6):e0158193. doi: 10.1371/journal.pone.0158193. eCollection 2016. PubMed PMID: 27351829; PubMed Central PMCID: PMC4924629.


  1. Thronicke A, Heger N, Antweiler E, Krannich A, Roehmel J, Brandt C, Staab D, Tintelnot K, Schwarz C. Allergic bronchopulmonary aspergillosis is associated with pet ownership in cystic fibrosis. Pediatr Allergy Immunol. 2016 Sep;27(6):597-603. doi: 10.1111/pai.12590. Epub 2016 Jun 1. PubMed PMID: 27145047.


  1. Storm C, Wutzler A, Trenkmann L, Krannich A, von Rheinbarben S, Luckenbach F, Nee J, Otto N, Schroeder T, Leithner C. Good neurological outcome despite very low regional cerebral oxygen saturation during resuscitation–a prospective preclinical trial in 29 patients. Scand J Trauma Resusc Emerg Med. 2016 Apr 6;24:43. doi: 10.1186/s13049-016-0234-3. PubMed PMID: 27048406; PubMed Central PMCID: PMC4822235.


  1. Hunsicker O, Krannich A, Spies C, Feldheiser A. Association of Sodium Homeostasis with Blood Transfusions During Liver Transplantation. Anesth Analg. 2016 Mar;122(3):916-7. doi: 10.1213/ANE.0000000000001057. PubMed PMID: 26891401.


  1. Wolke J, Herrmann DA, Krannich A, Scheibel M. Influence of Bony Defects on Preoperative Shoulder Function in Recurrent Anteroinferior Shoulder Instability. Am J Sports Med. 2016 May;44(5):1131-6. doi: 10.1177/0363546515626541. Epub 2016  Feb 17. PubMed PMID: 26888879.


  1. Tafelski S, Yi H, Ismaeel F, Krannich A, Spies C, Nachtigall I. Obesity in critically ill patients is associated with increased need of mechanical ventilation but not with mortality. J Infect Public Health. 2016 Sep-Oct;9(5):577-85. doi: 10.1016/j.jiph.2015.12.003. Epub 2016 Jan 2. PubMed PMID: 26754202.


  1. Brandl A, Stolzlechner P, Eschertzhuber S, Aigner F, Weiss S, Vogel W, Krannich A, Neururer S, Pratschke J, Graziadei I, Öllinger R. Inferior graft survival of hepatitis B core positive grafts is not influenced by post-transp ant hepatitis B infection in liver recipients–5-year single-center experience. Transpl Int. 2016 Apr;29(4):471-82. doi: 10.1111/tri.12741. Epub 2016 Feb 1. PubMed PMID: 26716608.



Publications 2015


  1. Hunsicker O, Fotopoulou C, Pietzner K, Koch M, Krannich A, Sehouli J, Spies C, Feldheiser A. Hemodynamic Consequences of Malignant Ascites in Epithelial Ovarian Cancer Surgery*: A Prospective Substudy of a Randomized Controlled Trial. Medicine (Baltimore). 2015 Dec;94(49):e2108. doi: 10.1097/MD.0000000000002108. PubMed PMID: 26656336; PubMed Central PMCID: PMC5008481.


  1. Maier A, Deigendesch N, Müller K, Weishaupt JH, Krannich A, Röhle R, Meissner F, Molawi K, Münch C, Holm T, Meyer R, Meyer T, Zychlinsky A. Interleukin-1 Antagonist Anakinra in Amyotrophic Lateral Sclerosis–A Pilot Study. PLoS One. 2015 Oct 7;10(10):e0139684. doi: 10.1371/journal.pone.0139684. eCollection 2015. PubMed PMID: 26444282; PubMed Central PMCID: PMC4596620.
  2. Lerchl K, Rakova N, Dahlmann A, Rauh M, Goller U, Basner M, Dinges DF, Beck L, Agureev A, Larina I, Baranov V, Morukov B, Eckardt KU, Vassilieva G, Wabel P, Vienken J, Kirsch K, Johannes B, Krannich A, Luft FC, Titze J. Agreement between  24-hour salt ingestion and sodium excretion in a controlled environment. Hypertension. 2015 Oct;66(4):850-7. doi: 10.1161/HYPERTENSIONAHA.115.05851. Epub  2015 Aug 10. PubMed PMID: 26259596; PubMed Central PMCID: PMC4567387.


  1. Hansen P, Hecht J, Ibrahim DM, Krannich A, Truss M, Robinson PN. Saturation analysis of ChIP-seq data for reproducible identification of binding peaks. Genome Res. 2015 Sep;25(9):1391-400. doi: 10.1101/gr.189894.115. Epub 2015 Jul 10. PubMed PMID: 26163319; PubMed Central PMCID: PMC4561497.


  1. Balzer F, Weiß B, Kumpf O, Treskatsch S, Spies C, Wernecke KD, Krannich A, Kastrup M. Early deep sedation is associated with decreased in-hospital and two-year follow-up survival. Crit Care. 2015 Apr 28;19:197. doi: 10.1186/s13054-015-0929-2. PubMed PMID: 25928417; PubMed Central PMCID: PMC4435917.


  1. Tafelski S, Nachtigall I, Troeger U, Deja M, Krannich A, Günzel K, Spies C; ABx Study Group. Observational clinical study on the effects of different dosing regimens on vancomycin target levels in critically ill patients: Continuous versus intermittent application. J Infect Public Health. 2015 Jul-Aug;8(4):355-63. doi: 10.1016/j.jiph.2015.01.011. Epub 2015 Mar 17. PubMed PMID: 25794497.


  1. Mähler A, Steiniger J, Bock M, Klug L, Parreidt N, Lorenz M, Zimmermann BF, Krannich A, Paul F, Boschmann M. Metabolic response to epigallocatechin-3-gallate in relapsing-remitting multiple sclerosis: a randomized clinical trial. Am J Clin Nutr. 2015 Mar;101(3):487-95. doi: 10.3945/ajcn.113.075309. Epub 2015 Jan 14. PubMed PMID: 25733633.


  1. Kork F, Balzer F, Krannich A, Weiss B, Wernecke KD, Spies C. Association of comorbidities with postoperative in-hospital mortality: a retrospective cohort study. Medicine (Baltimore). 2015 Feb;94(8):e576. doi: 10.1097/MD.0000000000000576. PubMed PMID: 25715258; PubMed Central PMCID: PMC4554144.



Publications 2014


  1. Stockmann H, Krannich A, Schroeder T, Storm C. Therapeutic temperature management after cardiac arrest and the risk of bleeding: systematic review and meta-analysis. 2014 Nov;85(11):1494-503. doi: 10.1016/j.resuscitation.2014.07.018. Epub 2014 Aug 15. Review. PubMed PMID: 25132475.


  1. Storm C, Leithner C, Krannich A, Wutzler A, Ploner CJ, Trenkmann L, von Rheinbarben S, Schroeder T, Luckenbach F, Nee J. Regional cerebral oxygen saturation after cardiac arrest in 60 patients–a prospective outcome study. 2014 Aug;85(8):1037-41. doi: 10.1016/j.resuscitation.2014.04.021. Epub 2014 Apr 30. PubMed PMID: 24795284.


  1. Klein F, Jacob D, Bahra M, Pelzer U, Puhl G, Krannich A, Andreou A, Gül S, Guckelberger O. Prognostic factors for long-term survival in patients with ampullary carcinoma: the results of a 15-year observation period after pancreaticoduodenectomy. HPB Surg. 2014;2014:970234. doi: 10.1155/2014/970234. Epub 2014 Mar 2. PubMed PMID: 24723741; PubMed Central PMCID: PMC3958923.


  1. Langelotz C, Mueller-Rau C, Terziyski S, Rau B, Krannich A, Gastmeier P, Geffers C. Gender-Specific Differences in Surgical Site Infections: An Analysis of 438,050 Surgical Procedures from the German National Nosocomial Infections Surveillance System. 2014 Apr;30(2):114-7. doi: 10.1159/000362100. PubMed PMID: 26288585; PubMed Central PMCID: PMC4513817.


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